The Cleveland Clinic Study: If You Get More Doses, You Put Others at Higher Risk
June 1 | Posted by mrossol | Science, Vaccine
Finally, after peer review, the Cleveland clinic study that report that “The higher the number of vaccines previously received, the higher the risk of contracting COVID-19” has been properly published.
“Risk of COVID-19… increased with time since most recent prior COVID-19 episode and with the number of vaccine doses previously received.’
https://academic.oup.com/ofid/advance-article/doi/10.1093/ofid/ofad209/7131292
See their Fig 2. ZERO doses had the lowest incidence of COVID-19, and more doses means more COVID.
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The authors wrote:
“During an Omicron wave in Iceland, individuals who had previously received 2 or more doses were found to have a higher odds of reinfection than those who had received fewer than 2 doses of vaccine, in an unadjusted analysis [21]. A large study found, in an adjusted analysis, that those who had an Omicron variant infection after previously receiving three doses of vaccine had a higher risk of reinfection than those who had an Omicron variant infection after previously receiving two doses of vaccine [22]. Another study found, in multivariable analysis, that receipt of two or three doses of a mRNA vaccine following prior COVID-19 was associated with a higher risk of reinfection than receipt of a single dose [7]. Immune imprinting from prior exposure to different antigens in a prior vaccine [22,23], and class switch towards non-inflammatory spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination [24], have been suggested as possible mechanisms by why prior vaccine may provide less protection than expected. We still have a lot to learn about protection from COVID-19 vaccination, and in addition to a vaccine’s effectiveness, it is important to examine whether multiple vaccine doses given over time may not be having the beneficial effect that is generally assumed.”
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